Congrats are in order to three students in our lab. Horacio Garcia received a NIDDK summer fellowship award to work in our lab this summer. Anike Zalyte and Karlyn Dobritch both received an INBRE NIH summer fellowship as well. Marty Schiller gave at talk at the University of Nevada Reno on Software tools for discovering new functions in proteins. This month papers on using genetic interaction to reduce false positive prediction of minimotifs (PMID: 22403687) and the structure of the DH1 domain of Kalirin (PMID: 22314704) were published. These were in collaboration with the Rajasekaran and Hoch groups, respectively. The Bio-toolkit is now active on Twitter.

A paper in collaboration with Shawn Li and Edwin Wang was published in Genome Research. This paper shows that phosphotyrosine signaling minimotifs are much more prevalent in higher metazoans and suggest that minimotifs play a significant role in the evolution of multicellularity. The new update to Minimotif Miner was published in the annual Nucleic Acids Res. database issue. This paper also has corrections to our model for minimotifs. Marty will present and has help organize the 2nd IEEE International Conference on Computational Advances in Bio and Medical Sciences (ICCABS) held this February in Las Vegas. Marty will also present the Bio-tookit at the 2012 Metabolomics conference.

The new release of Minimotif Miner 3 has ~300,000 minimotifs and a new filter algorithm that vastly reduces false positives. This paper will appear in the 2012 Nucleic Acids Research Database issue. Thus far, minimotif miner has now had ~43,000 searches performed. This month we are also releasing a prepublication version of our new HIVAtlas application. A paper reporting the structure of of the DH1 domain of Kalirin was accepted for publication

HIVToolbox is now used over 10,000 times. Martin Schiller was voted for promotion to Full Professor at the Departmental level. We welcome Sean Tuggle to the lab and bid farewell to Dorothea Maza, who is getting ready for Optometry school and also to Sandeep Deverasetty who is now working on a Genome sequencing project at UCLA (Sandeep's farewell shown). We also Welcome Astha Bajpai and Surbhi Sharma to the lab as new graduate students in the School of Life Sciences. We also are pleased to start a new collaboration with Dr. Ernesto Abel-Santos and his students Horacio Garcia and Mistry. They will be synthesizing some new lead compounds for treating HIV based on our bioinformatic based drug design.

Andy Brooks and Max Olsen complete their summer projects and presented a poster at the Undergraduate Research Day. The picture to the left shows Andy describing his work to Dean Porter. Alex Navarro Harrison presented his summer project examining the TrkA Kalirin interaction at NIH. We are happy that Andy and Alex will be continuing in the lab. We also welcome our new collaboration with Dr. Ernesto Abel Santos and his students Horacio Garcia and Mistry Sabyasachi who are designing new HIV drugs designed by graduate student David Sargeant. It seems like former student Jay Vyas is having trouble completing his dissertation at the University of Connecticut. This comical video accurately documents the recent history of Jay's trials and tribulations in his ongoing effort working toward his Ph.D.

HIVToolbox reaches 7500 searches in second month.

We welcome three new students to the lab for summer fellowship on the REU/NSF and STEP UP/NIDDK programs at UNLV. Shown are Max Olsen who comes to us from Utah State University and Andy Brooks from RPI. Alex Navarro-Harrison is also working on a HIV-1 project in the lab this summer. Logan Lee is also back and will be working on building our BioPod data warehouse. Marty Schiller gave two seminars at the Western IDeA Scientific Conference on the Bio-toolkit and on the UNLV Grant Club. HIVToolbox usage passes 6000 searches during its first month after publication in PLoS One.

HIVToolbox paper was published in PLoS One. Also we are pleased to announce that proteins structure links in the Protein Data Bank are now linked to HIVToolbox.

We welcome soon to be Dr. Christy Strong to the lab who will be a postdoctoral fellow. We also welcome two new graduate students, Astha Bajpai and Subrhi Sharma who will be entering the School of Life Sciences graduate program this fall. Also we are pleased to announce that proteins structure links in the Protein Data Bank will be linked to HIVToolbox in their April/2011 release.

Paper on SciReader is accepted, Lab has first annotation bootcamp to annotation data for OROMiner. Masters students Pat Gradie and Mike Rogers are leaving the lab to pursue jobs in industry - best wishes. We welcome undergraduate student Esra Nassar into the lab.

Schiller lab presents posters and talks at Rocky Mountain Bioinformatics Conference. Mike Rogers, MS student in computer science presented his work on ORO Miner. Dave Sargeant presented a poster on HIVToolbox, and Pat Gradie presented a poster on SciReader. Marty Schiller has a paper accepted on a new gene in Hearing in collaboration with the Hearing Consortia.

We welcome several new Undergraduates to the lab including Nicki Cohen and Parris Crooks, and Emily Tamadonfar. We also received a new R01 grant from the National Institutes of Health with our collaborator (Sanguthevar Rajasekaran, PI of grant). This is to develop new algorithms for identifying minimotifs. Martin Schiller is teach Cellular and Molecular Biology this semester (BIO 196). We have submitted a new proposal to continue or HIVToolbox project. The HIVToolbox was released this month. See the new website from the virus icon.

A paper in Proteins was just accepted. This paper describes a new filter in Minimotif Miner that has two purposes. You can now identify minimotifs that provide mechanisms for protein-protein interactions and can also filter minimotif predictions restricting them to proteins that are already known to interact in one of the 5 major protein-protein interaction databases. Marty will be teaching Cellular and Molecular Biology (BIOL 196) this semester. We would also like to thank our summer students Logan Li, Cory Russo, and Narineh Abadian. Logan will continue to help us build our data warehouse.

Our paper that uses cellular and molecular function from the Gene Ontology database was accepted for publication in PLoS One. We also welcome Tia Maza to the lab who is working on our model for HIV drugs and drug resistance. Also this month Mike Rogers has decided to do his Masters thesis work in our lab. Mike has already made significance contributions by building this website and developing and implementing the OROMiner model.

MimoSA is our new application for annotating Minimotifs. Congrats to first authors Jay Vyas and RJ Nowling, and to coauthors David Sargeant and Tom Meusburger for their first authored paper. Also this month, David Sargeant completes our 90 TB storage drive that will house our new Biowarehouse of biological data. Sandeep Deverasetty, David Sargeant, Patrick Gradie, Michael Rogers, and Chris Ross are starting to build this massive database.

Schiller lab publishes a paper with Shawn Li's group that was in Science Signaling. The new Bio-toolkit website was released. This brings all of the applications built by the Schiller and Gryk labs to a common website. A beta version of the human Anatomy, Histology, and Physiology database is released. Check it out !

The new Schiller lab webpage was released (schillerlab.bio-toolkit.com). Congrats and Thanks to Mike Rogers who designed this web page using Django. The renovation of the Bioinformatics lab is near completion. We were forced to keep a laboratory hood. We have named it "The Raymond DeFilippis Memorial Bioinformatics Hood"

Pat Gradie presents his work on a new reading environment for scientific content and Prashant Singh presents the labs work on development of a integrated model for human anatomy, development and physiology. Marty to serve as grant reviewer for Israel Science Foundation.

Renovation on our new Bioinformatics lab starts. It is expected to be done by the beginning of April.

Patrick Gradie, a previous undergrad collaborator who worked on Minimotif Miner release 2 joins lab as a software developer and plans to work on his Computer Science dissertation in the Schiller lab starting this fall. Dayne West got a job and moved on. We wish him well. Dayne completed several small projects related to our anticipated Stem cell database. Marty Started teaching his first class at UNLV on Great Biological Discoveries

Our University of Connecticut collaborators came to visit UNLV. This was a productive visit. Marty gave a short talk to the Nevada Board of Reagents on the labs research. Schiller and Shen labs propose a new Bioinformatics division in the School of Life Sciences, which is supported by several faculty in the department. Mike Rogers from Computer Science joins lab. Mike will work on our new website, the Bio-toolkit website and the Stem Cell databases

The lab had a party for Thanksgiving. The laboratory presented a poster at the Human Proteome Organization on minimotif semantics. Marty went to the school of Life Sciences faculty retreat.

We welcome Sandeep Deverasetty to the lab who will be working as a computer programmer/Database Administrator. The laboratory also received and ARRA supplement for our grant on minimotifs in HIV. An article in the Las Vegas Sun featured the research of our lab.

Dave Sargeant from Computer Science also joined the laboratory as a graduate student. Dave will work on the HIV Bioinformatics tool. We welcome a bunch of new undergraduates (Sahar Azim , Izua Alaniz , Caroline Chang , Farah Chowdhury , Keith Chung , Teinesha Irvey , Kate Keesling , Dave Lacambacal , Darlene Lara , Brian Lempa , Kyle Martin , Thomas Meusburger , Shruti Patel , Jacqueline Phan , Viraj Rathnayake , Brandon Roe , , Sherrie Serranno , Briana Sugihara , Thao Hoang , Paula Watts , Dayne West , Anike Zalyte , Stephanie Zobrist , Mike Rogers , Melissa Cope , Alex Spelman) to the new UNLV lab. We also moved into our new lab in WHI 119 and new Office in WHI 117.

Dr. Prashant Singh joined the lab to work on a Stem cell related project. Welcome aboard. We also released a new application called Venn (download page, publication). Our paper proposing a functional syntax for Minimotifs was also accepted. Congrats to student Jay Vyas who was the first author on both papers which were accepted on the same day, forever designated as JayDay. We formed a grant club of investigators at UNLV that meets weekly with the goal of increasing UNLV funding and resources.

The Schiller Lab has moved the University of Nevada Las Vegas in the School of Life Sciences.

An abstract for the HUPO 2009 congress on Minimotif semantics was accepted. Marty Schiller is serving on NIH study section for review of Challenge Grants. Marty will give a talk on the new release of MnM-HIV at the 23rd Annual Meeting of the Groups Studying the Structures of AIDS-Related Systems and Their Application to Targeted Drug Design sponsored by the National Institute of General Medical Sciences. The 2nd annual Gryk-Schiller beach party was a success. We enjoyed some Frisbee in the surf, shrimp and filet on the barby and some great company. For the second year running Jay Vyas from the Gryk lab came up short in the horse shoe competition losing to the rookie Marek Barwinski.

Schiller lab to move to UNLV this summer. We will miss all of our UCHC colleagues. Angel Villahoz Baleta presents the MnM-HIV website at the Center for Cell Analysis and Modeling.

Angel Villahoz Baleta will present his work on the MnM-HIV website at the yearly MMSB retreat. MnM reaches 31,000 searches.

Angel Villahoz Baleta gets a alpha version of MnM-HIV running. We are anticipating the first release soon. Several groups have agreed to share data with us for the MnM-HIV website. This includes the Los Alamos National Laboratory HIV database, the Stanford HIV Drug Resistance Database, Southern Research Institute HIV Protein-Protein Interaction database, and NIST HIV Structure database. We welcome these new collaborations. Shawn Li visits UCHC and give a talk on his work on minimotifs - he has presented some amazing work. Diana Finzi, our NIAID program officer has been a great asset in helping us on the MnM-HIV project- Thank you. We welcome Rinu Thomas to the lab who will be working on the new stem cell database project. Schiller/Gryk labs start a joint weekly journal club.

Marty Schiller gives talk at University of North Carolina, Charlotte, Bioinformatics Department. Marek Barwinski joins the lab and is starting a project solving the structure of several SH2 domains in collaboration with a long time collaborator in MMSB, Mark Maciejewski. Welcome Marek. Marty Schiller serves on the Connecticut Academy of Science Review Panel.

Marty Schiller gives talk at University of Nevada Las Vegas School of Life Sciences.

A new version of Minimotif Miner was released MnM 2. The new release was published in the Database issue of Nucleic Acids Research. Jay Vyas and Krishna present their progress talks in the MMSB department.

Lab receives a collaborative University grant with Drs. Craig Nelson at the University of Connecticut and Michael Gryk, a long time collaborator in the MMSB department. This goal of this seed grant is to develop a stem cell database.

Marty Schiller gives talk on motifs and the New England Structure Biology Symposium .

Release of our Minimotif miner website was covered in the Journal of Proteome Research .

Release of our Minimotif miner website was covered in Science.